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KMID : 0363619990200010113
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Journal of Korean Oriental Medicine
1999 Volume.20 No. 1 p.113 ~ p.121
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GalhuaHaeJungTang Inhibit Ethanol-induced Gastric Injury in Rats
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Chae Jong-Koo
Shin Heung-Mook
Kim Gil-Whon
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Abstract
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This Study was carried out to investigate the protective effect of GalHwaHaJungTang(GHT) on the gastric lesions indused by ethanol in rats. Rats were pretreated with GHT extract 1.7ml/kg, 3.4ml/kg, 5ml/kg and then were given orally 1ml of absolute ethanol 30min later. The animals were killed 1hr after ethanol treatment In morphorogic change, ethanol induced prominent longitudinal hemorrhagic lesions in the stomach. But GHT-pretreatment showed a dose-depentent decrease in the mucosa lesions. GHT extract siginificantly reduced lipid peroxidation and also induced an increase of superoxide dismutase(SOD), catalase and gluthathion(GSH) levels, but showed no influence in the type conversion of xanthine oxidase. These results suggest that the proposed gastroprotective effect may involve activation of antioxidant effects, but independent of the xanthine oxidase system.
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KEYWORD
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GalHwaHaJungTang(GHT), superoyide dismutase, catalase, gluthathion, lipid peroxidation
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